Current position:Content
Research content
1. To design and synthesize multiple recognition molecules and biological probes to obtain accurate quantitative information of neurochemical molecules,
2. To construct a stable self-assembly and anti-fouling interface to achieve long-term measurement of the freely moving animals,
3. To create new instruments and new equipment with high spatial and temporal resolution in researching freely moving animals.

Representative publications
1、J. Am. Chem. Soc. 2022, 144, 5, 2351–2359
Pillar[5]arene-Based Fluorescent Sensor Array for Biosensing of Intracellular Multi-neurotransmitters through Host–Guest Recognitions.
Link: https://pubs.acs.org/doi/10.1021/jacs.1c12959
2、Angew. Chem. Int. Ed. 2022, 61, e2021116
Raman Fiber Photometry for Understanding Mitochondrial Superoxide Burst and Extracellular Calcium Ion Influx upon Acute Hypoxia in the Brain of Freely Moving Animals.
Link: https://onlinelibrary.wiley.com/doi/10.1002/advs.202104790
3Adv. Sci. 2022,9, 2104790
Time-Resolved Encryption via a Kinetics-Tunable Supramolecular Photochromic System.
Link: https://onlinelibrary.wiley.com/doi/10.1002/advs.202104790
4、Angew. Chem. Int. Ed. 2021, 60, 26260–26267
Ultrasensitive Sensing of Volatile Organic Compounds Using a Cu-Doped SnO2-NiO p-n Heterostructure That Shows Significant Raman Enhancement.
Link: https://doi.org/10.1002/anie.202106193
5, Angew. Chem. Int. Ed. 2021, 60, 21351-21359.
Real-time Tracking and Sensing of Cu+ and Cu2+ with a Single SERS Probe in the Live Brain: Toward Understanding Why Copper Ions Were Increased upon Ischemia.
Link: https://doi.org/10.1002/anie.202106193
6、Angew. Chem. Int. Ed. 2021, 60, 14429-14437.
Long-Term Tracking and Dynamically Quantifying of Reversible Changes of Extracellular Ca2+ in Multiple Brain Regions of Freely Moving Animals.
Link: https://onlinelibrary.wiley.com/doi/10.1002/anie.202102833
7、J. Am. Chem. Soc. 2020, 142, 16, 7532–7541
Real-Time Imaging and Simultaneous Quantification of Mitochondrial H2O2 and ATP in Neurons with a Single Two-Photon Fluorescence-Lifetime-Based Probe.
Link: https://onlinelibrary.wiley.com/doi/10.1002/anie.202006318
8, Angew. Chem. Int. Ed., 2020, 59, 20499-20507.
A Robust Au−C≡C Functionalized Surface: Toward Real-Time Mapping and Accurate Quantification of Fe2+ in the Brains of Live AD Mouse Models.
Link: https://onlinelibrary.wiley.com/doi/10.1002/anie.202006318
9、Angew. Chem. Int. Ed., 2020, 59, 10426-10430.
An Electrochemophysiological Microarray for Real-Time Monitoring and Quantification of Multiple Ions in the Brain of a Freely Moving Rat.
Link:https://onlinelibrary.wiley.com/doi/full/10.1002/anie.202002417
10, iScience, 2020, 23, 101344
A DNA-Based FLIM Reporter for Simultaneous Quantification of Lysosomal pH and Ca2+ during Autophagy Regulation.
Link: https://www.cell.com/iscience/fulltext/S2589-0042(20)30531-9
11. Chem. Sci., 2020, 11, 2215-2224.
A novel two-photon ratiometric fluorescent probe for imaging and sensing of BACE1 in different regions of AD mouse brain.
Link: https://pubs.rsc.org/en/content/articlelanding/2020/sc/c9sc05256a#!divAbstract
12. Angew. Chem. Int. Ed., 2019, 59, 7757-7761.
Functionalized h-BN Nanosheets as a Theranostic Platform for SERS Real-Time Monitoring of MicroRNA and Photodynamic Therapy.
Link: https://doi.org/10.1002/anie.201902776
13,Angew. Chem. Int. Ed., 2019, 58, 13948-13953.
Rational Design of Specific Recognition Molecules for Simultaneously Monitoring of Endogenous Polysulfide and Hydrogen Sulfide in the Mouse Brain.
Link: https://doi.org/10.1002/anie.201907210
14, Angew. Chem. Int. Ed., 2019, 58, 5256-5260.
A SERS Optophysiological Probe for the Real-Time Mapping and Simultaneous Determination of the Carbonate Concentration and pH Value in a Live Mouse Brain.
Link: https://onlinelibrary.wiley.com/doi/full/10.1002/anie.201814286
15, J. Am. Chem. Soc. 2019, 141, 22, 8943–8950
Light-Controlled Generation of Singlet Oxygen within a Discrete Dual-Stage Metallacycle for Cancer Therapy.
Link: https://pubs.acs.org/doi/10.1021/jacs.9b02726
16、Acc. Chem. Res. 2018, 51, 3, 688–696
Designing Recognition Molecules and Tailoring Functional Surfaces for In Vivo Monitoring of Small Molecules in the Brain.
Link: https://doi.org/10.1021/acs.accounts.7b00543
17、ACS Nano 2018, 12, 12, 12357–12368
Mitochondria-Targeted DNA Nanoprobe for Real-Time Imaging and Simultaneous Quantification of Ca2+ and pH in Neurons.
Link: https://doi.org/10.1021/acsnano.8b06322
18. Sci. Adv., 2018, 4, eaau3494.
A novel ternary heterostructure with dramatic SERS activity for evaluation of PD-L1 expression at the single-cell level.
Link: https://advances.sciencemag.org/content/4/11/eaau3494
19、Angew. Chem. Int. Ed., 2017, 56, 16328-16332.
Development of an Efficient Biosensor for the In Vivo Monitoring of Cu+ and pH in the Brain: Rational Design and Synthesis of Recognition Molecules.
Link: http://10.1002/anie.201710863
20、Angew. Chem. Int. Ed., 2017, 56, 10471-10475.
An Electrochemical Biosensor with Dual Signal Outputs: Toward Simultaneous Quantification of pH and O2 in the Brain upon Ischemia and in a Tumor during Cancer Starvation Therapy
Link: https://doi.org/10.1002/ange.201705615
21. Angew. Chem. Int. Ed., 2015, 54, 14053-14056.
A Single Biosensor for Evaluating the Levels of Copper Ion and L-Cysteine in a Live Rat Brain with Alzheimer's Disease.
Link:https://doi.org/10.1002/anie.201508635
22. Angew. Chem. Int. Ed., 2013, 52, 8129-8133.
A Two-Channel Ratiometric Electrochemical Biosensor for In Vivo Monitoring of Copper Ions in a Rat Brain Using Gold Truncated Octahedral Microcages.
Link: https://doi.org/10.1002/anie.201302958
23. Adv. Mater., 2012, 24, 5844-5848.
Carbon Dot-Based Inorganic–Organic Nanosystem for Two-Photon Imaging and Biosensing of pH Variation in Living Cells and Tissues.
Link: https://doi.org/10.1002/adma.201202599
24. Angew. Chem. Int. Ed., 51 (29) (2012), 7185-7189.
Carbon-Dot-Based Dual-Emission Nanohybrid Produces a Ratiometric Fluorescent Sensor for In Vivo Imaging of Cellular Copper Ions.
Link:https://doi.org/10.1002/ange.201109089
25. Angew. Chem. Int. Ed., 2011, 50, 1837-1840.
Sensitive and Selective Colorimetric Visualization of Cerebral Dopamine Based on Double Molecular Recognition.
Link:https://doi.org/10.1002/anie.201007071
26、J. Am. Chem. Soc., 2005, 127, 7632-7637.
Mechanisms and Applications of Plasmon-Induced Charge Separation at TiO2 Films Loaded with Gold Nanoparticles.
Link: https://doi.org/10.1021/ja042192u